Glibenclamide 5 mg Tablet (also known as Glyburide) is an oral anti-diabetic medication belonging to the sulfonylurea class. It is used to control blood sugar levels in patients with type 2 diabetes mellitus. By stimulating the pancreas to produce more insulin, it helps lower blood sugar and prevents diabetes-related complications.
Key Benefits:
Effectively lowers blood sugar levels in type 2 diabetes
Reduces the risk of diabetes complications like nerve damage and kidney disease
Helps in long-term diabetes management when combined with diet and exercise
Can be used alone or with other anti-diabetic medications (like metformin)
How It Works:
Glibenclamide stimulates insulin secretion from the pancreas, helping the body utilize glucose more effectively. It also reduces excess glucose production in the liver, leading to improved blood sugar control.
How to Take Glibenclamide 5mg Tablet:
- Take before or with breakfast, as directed by your doctor.
- Swallow whole with water—do not crush or chew.
- Stick to a regular schedule to maintain consistent blood sugar levels.
- Monitor blood sugar levels regularly to avoid hypoglycemia (low blood sugar).
Possible Side Effects:
- Hypoglycemia (low blood sugar) – symptoms include dizziness, sweating, hunger, and shaking
- Nausea or stomach discomfort
- Weight gain (due to increased insulin activity)
- Skin reactions (rash, itching in rare cases)
- Liver enzyme changes (rare, but should be monitored in long-term use)
Severe side effects are rare but may include allergic reactions, severe hypoglycemia, or liver dysfunction. Seek medical attention if serious symptoms occur.
Precautions & Warnings:
Not for type 1 diabetes or diabetic ketoacidosis
Use with caution in elderly patients, as they are more prone to low blood sugar
Avoid alcohol, as it can increase the risk of low blood sugar
Not suitable for pregnant or breastfeeding women—alternative diabetes treatments should be considered
Use with caution in patients with kidney or liver disease
Frequently Asked Questions (FAQs)
1. How long does Glibenclamide 5 mg take to lower blood sugar?
It starts working within 1-2 hours, with peak effects in 2-6 hours.
2. Can Glibenclamide cause weight gain?
Yes, it may cause mild weight to gain due to increased insulin activity.
3. What should I do if I miss a dose?
Take it as soon as you remember before your next meal. Do not double the dose.
4. Can I take Glibenclamide with Metformin?
Yes, they are often prescribed together to improve blood sugar control.
5. What should I do if I experience hypoglycemia?
Consume fast-acting sugar (glucose tablets, fruit juice, or candy) and consult your doctor if frequent episodes occur.
6. Can Glibenclamide be taken long-term?
Yes, but regular blood sugar monitoring and kidney/liver function tests are recommended.
7. Is Glibenclamide better than newer diabetes medications?
It is effective but may cause more hypoglycemia compared to newer options like DPP-4 inhibitors or GLP-1 receptor agonists.
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