TIGI 50mg Injection

What is TIGI 50mg Injection?

TIGI 50mg Infusion contains Tigecycline, a wide range anti-toxin from the glycylcycline class. It is used to treat severe bacterial infections caused by susceptible microorganisms.

Common Uses:

• Complicated intra-abdominal infections (cIAI).
• Complicated skin and soft tissue infections (cSSTI).
• Community-acquired bacterial pneumonia (CABP).
• Infections caused by multi-drug-resistant bacteria, including certain strains of MRSA (Methicillin-resistant Staphylococcus aureus) and VRE (Vancomycin-resistant Enterococci).

What are the Benefits of Using TIGI 50mg Injection?

1. Broad-Spectrum Activity:
   • Successful against an extensive variety of Gram-positive, Gram-negative, anaerobic, and abnormal microbes.
2. Treatment of Resistant Infections:
   • Especially useful for infections caused by multi-drug-resistant pathogens.
3. Hospital-Based Use:
   • Suitable for critically ill patients with severe infections requiring intravenous antibiotic therapy.
4. Fewer Drug Interactions:
   • Tigecycline has minimal interactions with other medications, making it suitable for patients with complex conditions.

How to Use TIGI 50mg Injection?

1. Dosage:
   • The usual starting dose is 100mg intravenously, followed by 50mg every 12 hours.
   • Treatment duration varies from 5 to 14 days, depending on the infection type and severity.
2. Administration:
   • Given as an intravenous infusion over 30 to 60 minutes by a healthcare professional.
   • Ensure the injection is prepared and administered under sterile conditions.
3. Storage:
   • Store in a refrigerator (2°C–8°C). Reconstituted solution should be used within the specified time as per the healthcare provider’s guidelines.

Strengths and Substitutes for TIGI 50mg Injection

Strengths:

• TIGI 50mg Injection: Standard dose.

Substitutes:
If TIGI 50mg is unavailable, consider other Tigecycline-based formulations, such as:

1. Tygacil Injection (Tigecycline)
2. Tigecycline Cipla Injection
3. Ticocin Injection

What are the Side Effects of TIGI 50mg Injection?

1. Common Side Effects:
   • Nausea and vomiting.
   • Diarrhea.
   • Abdominal pain.
2. Less Common Side Effects:
   • Injection site reactions (pain, redness).
   • Headache or dizziness.
   • Rash or itching.
3. Serious but Rare Side Effects:
   • Severe allergic reactions: Swelling, difficulty breathing, or rash.
   • Pancreatitis: Severe abdominal pain, nausea, or vomiting.
   • Liver brokenness: Yellowing of the skin or eyes, dull pee.
   • Clostridium difficile-associated diarrhea (CDAD): Severe, watery, or bloody diarrhea.

Contact your doctor immediately if you experience any severe or unusual symptoms.

Safety Advice for TIGI 50mg Injection

1. Pregnancy and Breastfeeding:
   • Not recommended during pregnancy unless necessary. May harm the fetus.
   • Use during breastfeeding only if benefits outweigh risks.
2. Liver or kidney disease:
   • Dose adjustments may be needed for patients with liver dysfunction.
3. Driving and Machinery:
   • May cause dizziness or fatigue; avoid activities requiring alertness until you know how it affects you.
4. Avoid Overuse:
   • Overuse or misuse may lead to antibiotic resistance.
5. Drug Interactions:
   • Inform your doctor about all medications you’re taking. Tigecycline has minimal drug interactions but may interact with blood thinners like warfarin.
6. Allergies:
   • Inform your doctor if you are allergic to tetracycline antibiotics or similar drugs.

FAQs 

1. What types of bacteria does TIGI 50mg Injection treat?

• Tigecycline is effective against a broad range of bacteria, including MRSA, VRE, and certain Gram-negative organisms resistant to conventional antibiotics.

2. How long does it take to see improvement?

• Improvement usually occurs within a few days, but the full course must be completed to ensure complete eradication of the infection.

3. Can TIGI 50mg Injection treat urinary tract infections (UTIs)?

• Tigecycline is generally not recommended for UTIs as it achieves low concentrations in urine.

4. Is TIGI 50mg Injection safe for children?

• Safety in children under 18 years has not been established. Use in pediatric patients is not recommended unless necessary.

5. Can TIGI 50mg Injection cause antibiotic resistance?

• Like all antibiotics, misuse or incomplete courses of TIGI can contribute to resistance. Always follow your doctor’s instructions.

6. What should I do if I experience severe diarrhea during treatment?

• Severe diarrhea may indicate Clostridium difficile infection. Contact your doctor immediately.

7. How is TIGI different from other antibiotics?

• Tigecycline is structurally related to tetracyclines but works against bacteria resistant to tetracyclines, penicillins, and cephalosporins.

8. Can TIGI be used in combination with other antibiotics?

• Yes, it can be combined with other antibiotics for polymicrobial infections. Always consult your doctor for the appropriate regimen.

9. What happens if treatment is stopped prematurely?

• Stopping treatment early may lead to incomplete eradication of the infection and promote resistance.